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A global metagenomic map of urban microbiomes and antimicrobial resistance

dc.contributor.authorDanko, Daviden_GB
dc.contributor.authorBezdan, Danielaen_GB
dc.contributor.authorAfshin, Evan E.en_GB
dc.contributor.authorAhsanuddin, Sofiaen_GB
dc.contributor.authorBhattacharya, Chandrimaen_GB
dc.contributor.authorButler, Daniel J.en_GB
dc.contributor.authorChng, Kern Reien_GB
dc.contributor.authorDonnellan, Daisyen_GB
dc.contributor.authorHecht, Jochenen_GB
dc.contributor.authorJackson, Katelynen_GB
dc.contributor.authorKuchin, Katerinaen_GB
dc.contributor.authorKarasikov, Mikhailen_GB
dc.contributor.authorLyons, Abigailen_GB
dc.contributor.authorMak, Laurenen_GB
dc.contributor.authorMeleshko, Dmitryen_GB
dc.contributor.authorMustafa, Harunen_GB
dc.contributor.authorMutai, Bethen_GB
dc.contributor.authorNeches, Russell Y.en_GB
dc.contributor.authorNg, Amandaen_GB
dc.contributor.authorNikolayeva, Olgaen_GB
dc.contributor.authorNikolayeva, Tatyanaen_GB
dc.contributor.authorPng, Eileenen_GB
dc.contributor.authorRyon, Krista A.en_GB
dc.contributor.authorSanchez, Jorge L.en_GB
dc.contributor.authorShaaban, Hebaen_GB
dc.contributor.authorSierra, Maria A.en_GB
dc.contributor.authorThomas, Dominiqueen_GB
dc.contributor.authorYoung, Benen_GB
dc.contributor.authorAbudayyeh, Omar O.en_GB
dc.contributor.authorAlicea, Josueen_GB
dc.contributor.authorBhattacharyya, Malayen_GB
dc.contributor.authorBlekhman, Ranen_GB
dc.contributor.authorCastro-Nallar, Eduardoen_GB
dc.contributor.authorCañas, Ana M.en_GB
dc.contributor.authorChatziefthimiou, Aspassia D.en_GB
dc.contributor.authorCrawford, Robert W.en_GB
dc.contributor.authorDe Filippis, Francescaen_GB
dc.contributor.authorDeng, Youpingen_GB
dc.contributor.authorDesnues, Christelleen_GB
dc.contributor.authorDias-Neto, Emmanuelen_GB
dc.contributor.authorDybwad, Mariusen_GB
dc.contributor.authorElhaik, Eranen_GB
dc.contributor.authorErcolini, Daniloen_GB
dc.contributor.authorFrolova, Alinaen_GB
dc.contributor.authorGankin, Dennisen_GB
dc.contributor.authorGootenberg, Jonathan S.en_GB
dc.contributor.authorGraf, Alexandra B.en_GB
dc.contributor.authorGreen, Carolineen_GB
dc.contributor.authorHajirasouliha, Imanen_GB
dc.contributor.authorHastings, Jaden J.A.en_GB
dc.contributor.authorHernandez, Marken_GB
dc.contributor.authorIraola, Gregorioen_GB
dc.contributor.authorJang, Soojinen_GB
dc.contributor.authorKahles, Andreen_GB
dc.contributor.authorKelly, Frank J.en_GB
dc.contributor.authorKnights, Kaymishaen_GB
dc.contributor.authorKyrpides, Nikosen_GB
dc.contributor.authorŁabaj, Paweł P.en_GB
dc.contributor.authorLee, Patrick K.H.en_GB
dc.contributor.authorLeung, Marcus H.Y.en_GB
dc.contributor.authorLjungdahl, Per O.en_GB
dc.contributor.authorMason-Buck, Gabriellaen_GB
dc.contributor.authorMcGrath, Kenen_GB
dc.contributor.authorMeydan, Cemen_GB
dc.contributor.authorMongodin, Emmanuel F.en_GB
dc.contributor.authorMoraes, Milton Ozorioen_GB
dc.contributor.authorNagarajan, Niranjanen_GB
dc.contributor.authorNieto-Caballero, Marinaen_GB
dc.contributor.authorNoushmehr, Houtanen_GB
dc.contributor.authorOliveira, Manuelaen_GB
dc.contributor.authorOssowski, Stephanen_GB
dc.contributor.authorOsuolale, Olayinka O.en_GB
dc.contributor.authorÖzcan, Orhanen_GB
dc.contributor.authorPaez-Espino, Daviden_GB
dc.contributor.authorRascovan, Nicolásen_GB
dc.contributor.authorRichard, Huguesen_GB
dc.contributor.authorRätsch, Gunnaren_GB
dc.contributor.authorSchriml, Lynn M.en_GB
dc.contributor.authorSemmler, Torstenen_GB
dc.contributor.authorSezerman, Osman U.en_GB
dc.contributor.authorShi, Lemingen_GB
dc.contributor.authorShi, Tieliuen_GB
dc.contributor.authorSiam, Raniaen_GB
dc.contributor.authorSong, Le Huuen_GB
dc.contributor.authorSuzuki, Haruoen_GB
dc.contributor.authorCourt, Denise Syndercombeen_GB
dc.contributor.authorTighe, Scott W.en_GB
dc.contributor.authorTong, Xinzhaoen_GB
dc.contributor.authorUdekwu, Klas I.en_GB
dc.contributor.authorUgalde, Juan A.en_GB
dc.contributor.authorValentine, Brandonen_GB
dc.contributor.authorVassilev, Dimitar I.en_GB
dc.contributor.authorVayndorf, Elena M.en_GB
dc.contributor.authorVelavan, Thirumalaisamy P.en_GB
dc.contributor.authorWu, Junen_GB
dc.contributor.authorZambrano, María M.en_GB
dc.contributor.authorZhu, Jifengen_GB
dc.contributor.authorZhu, Siboen_GB
dc.contributor.authorMason, Christopher E.en_GB
dc.date.accessioned2022-03-22T09:02:48Z
dc.date.accessioned2022-05-20T07:34:08Z
dc.date.available2022-03-22T09:02:48Z
dc.date.available2022-05-20T07:34:08Z
dc.date.issued2021-06-24
dc.identifier.citationDanko, Bezdan, Afshin, Ahsanuddin, Bhattacharya, Butler, Chng, Donnellan, Hecht, Jackson, Kuchin, Karasikov, Lyons, Mak, Meleshko, Mustafa, Mutai, Neches, Ng, Nikolayeva, Nikolayeva, Png, Ryon, Sanchez, Shaaban, Sierra, Thomas, Young, Abudayyeh, Alicea, Bhattacharyya, Blekhman, Castro-Nallar, Cañas, Chatziefthimiou, Crawford, De Filippis, Deng, Desnues, Dias-Neto, Dybwad, Elhaik, Ercolini, Frolova, Gankin, Gootenberg, Graf, Green, Hajirasouliha, Hastings, Hernandez, Iraola, Jang, Kahles, Kelly, Knights, Kyrpides, Łabaj, Lee, Leung, Ljungdahl, Mason-Buck, McGrath, Meydan, Mongodin, Moraes, Nagarajan, Nieto-Caballero, Noushmehr, Oliveira, Ossowski, Osuolale, Özcan, Paez-Espino, Rascovan, Richard, Rätsch, Schriml, Semmler, Sezerman, Shi, Shi, Siam, Song, Suzuki, Court, Tighe, Tong, Udekwu, Ugalde, Valentine, Vassilev, Vayndorf, Velavan, Wu, Zambrano, Zhu, Zhu, Mason. A global metagenomic map of urban microbiomes and antimicrobial resistance. Cell. 2021;184(13):3376-3393.e17en_GB
dc.identifier.urihttp://hdl.handle.net/20.500.12242/3025
dc.descriptionDanko, David; Bezdan, Daniela; Afshin, Evan E.; Ahsanuddin, Sofia; Bhattacharya, Chandrima; Butler, Daniel J.; Chng, Kern Rei; Donnellan, Daisy; Hecht, Jochen; Jackson, Katelyn; Kuchin, Katerina; Karasikov, Mikhail; Lyons, Abigail; Mak, Lauren; Meleshko, Dmitry; Mustafa, Harun; Mutai, Beth; Neches, Russell Y.; Ng, Amanda; Nikolayeva, Olga; Nikolayeva, Tatyana; Png, Eileen; Ryon, Krista A.; Sanchez, Jorge L.; Shaaban, Heba; Sierra, Maria A.; Thomas, Dominique; Young, Ben; Abudayyeh, Omar O.; Alicea, Josue; Bhattacharyya, Malay; Blekhman, Ran; Castro-Nallar, Eduardo; Cañas, Ana M.; Chatziefthimiou, Aspassia D.; Crawford, Robert W.; De Filippis, Francesca; Deng, Youping; Desnues, Christelle; Dias-Neto, Emmanuel; Dybwad, Marius; Elhaik, Eran; Ercolini, Danilo; Frolova, Alina; Gankin, Dennis; Gootenberg, Jonathan S.; Graf, Alexandra B.; Green, Caroline; Hajirasouliha, Iman; Hastings, Jaden J.A.; Hernandez, Mark; Iraola, Gregorio; Jang, Soojin; Kahles, Andre; Kelly, Frank J.; Knights, Kaymisha; Kyrpides, Nikos; Łabaj, Paweł P.; Lee, Patrick K.H.; Leung, Marcus H.Y.; Ljungdahl, Per O.; Mason-Buck, Gabriella; McGrath, Ken; Meydan, Cem; Mongodin, Emmanuel F.; Moraes, Milton Ozorio; Nagarajan, Niranjan; Nieto-Caballero, Marina; Noushmehr, Houtan; Oliveira, Manuela; Ossowski, Stephan; Osuolale, Olayinka O.; Özcan, Orhan; Paez-Espino, David; Rascovan, Nicolás; Richard, Hugues; Rätsch, Gunnar; Schriml, Lynn M.; Semmler, Torsten; Sezerman, Osman U.; Shi, Leming; Shi, Tieliu; Siam, Rania; Song, Le Huu; Suzuki, Haruo; Court, Denise Syndercombe; Tighe, Scott W.; Tong, Xinzhao; Udekwu, Klas I.; Ugalde, Juan A.; Valentine, Brandon; Vassilev, Dimitar I.; Vayndorf, Elena M.; Velavan, Thirumalaisamy P.; Wu, Jun; Zambrano, María M.; Zhu, Jifeng; Zhu, Sibo; Mason, Christopher E.. A global metagenomic map of urban microbiomes and antimicrobial resistance. Cell 2021 ;Volum 184.(13) s. 3376-3393.e17en_GB
dc.description.abstractWe present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria, 2 archaea, and 838,532 CRISPR arrays not found in reference databases. We identified 4,246 known species of urban microorganisms and a consistent set of 31 species found in 97% of samples that were distinct from human commensal organisms. Profiles of AMR genes varied widely in type and density across cities. Cities showed distinct microbial taxonomic signatures that were driven by climate and geographic differences. These results constitute a high-resolution global metagenomic atlas that enables discovery of organisms and genes, highlights potential public health and forensic applications, and provides a culture-independent view of AMR burden in cities.en_GB
dc.language.isoenen_GB
dc.subjectMetagenomikken_GB
dc.subjectMikroorganismeren_GB
dc.titleA global metagenomic map of urban microbiomes and antimicrobial resistanceen_GB
dc.typeArticleen_GB
dc.date.updated2022-03-22T09:02:48Z
dc.identifier.cristinID2010399
dc.identifier.doi10.1016/j.cell.2021.05.002
dc.source.issn0092-8674
dc.source.issn1097-4172
dc.type.documentJournal article
dc.relation.journalCell


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